Rice University
BioSciences at Rice

H. Michael Kohn

Associate Professor of BioSciences


Our lab employs molecular and bioinformatics tools to study the evolutionary dynamics of genes and genomes in populations and species. Some of our research projects have implications for conservation biology or medicine.  Much of our work is concerned with the evolutionary dynamics and medical effects of mutations in the vitamin K cycle genes, foremost vkorc1, in rats and mice that have developed a resistance to anticoagulant rodenticides such as warfarin.

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Liu, KJ, Steinberg, E, Yozzo, A, Song, Y, Kohn, MH, and L Nakhleh.  2015. Interspecific introgressive origin of genomic diversity in the house mouse. Proc. Nat. Acad. Sci., USA 112:196-201

Liu KJ, Dai J, Truong K, Song Y, Kohn MH, and L Nakhleh. 2014. An HMM-Based Comparative Genomic Framework for Detecting Introgression in Eukaryotes. PLoS Comput Biol 10(6): e1003649. doi:10.1371/journal.pcbi.1003649

Endepols, S., Klemann, N., Song, Y., and  Kohn, HM.  2013. vkorc1-Variation in house mice during Warfarin and Difenacoum field trials.  Pest Management Science 69:409-413.  doi: 10.1002/ps.3306

Ying Song, Stefan Endepols, Nicole Klemann, Dania Richter, Franz- Rainer Matuschka , Ching-Hua Shih, Michael Nachmann, Michael H. Kohn. 2011 Adaptive introgression of anticoagulant rodent poison resistance by hybridization between Old World mice.  Current Biology.  21:1296-1301

Julien Beuchat, Shuwei Li, Chikako Shindo, Michael H. Kohn, Christian S. Hardtke. (2010) A hyperactive quantitative trait locus allele of Arabidopsis BRX contributes to natural variation in root growth vigor. The Proceedings of the National Academy of Sciences, U.S.A. 107: (18) 8475-8480.

Juan C Diaz, Ying Song, Anthony Moore$, Jeff N Borchert and Michael H Kohn. (2010) Analysis of vkorc1 polymorphisms in Norway rats using the roof rat as outgroup. BMC Genetics 11:43

Shuwei Li, Ching-Hua Shih and Michael H Kohn. (2010) Functional and evolutionary correlates of gene constellations in the Drosophila melanogaster genome that deviate from the stereotypical gene architecture. BMC Genomics 11:322

Agnes Grandemange, Michael H. Kohn, Romain Lasseur, Christiane Longin-Sauvageon, Philippe Berny, Etienne Benoit. Consequences of the Y139F Vkorc1 mutation on resistance to AVKs - in vivo investigation in a 7th generation of congenic Y139F strain of rats. 2009.  Pharmacogenetics and Genomics. 19 (10):742-750.

Laurie S. Stevison and Michael H. Kohn. 2009. Divergence population genetic analysis of hybridization between Rhesus and Cynomolgus Macaques. Molecular Ecology 18 (11): 2457-2475.

Michael H Kohn, Roger E Price, Hans-Joachim Pelz. 2008.  A Cardiovascular phenotype in the Vkorc1 mutant warfarin-resistant rat Artery Research 2: 138-147.

Michael H Kohn, Joshua Shapiro and Chung-I Wu. 2008. Decoupled evolution of regulatory and coding regions of drosophila genes. Genes and Genetic Systems 83: 265-273.

Laurie S Stevison and Michael H Kohn. 2008.  Divergent genetic backgrounds in cynomolgus macaques (Macaca fascicularis) captive stocks. Journal Medical Primatology 37: 311 - 317

Michael H. Kohn. 2008. Rapid sequence divergence rates in the 5 prime regulatory regions of young Drosophila melanogaster duplicate gene pairs. Genetics and Molecular Biology 31: 575-584.

Ying Song, Nicole Vera, Michael H Kohn. 2008.  Vitamin K epoxide reductase (Vkorc1) haplotype variation in priority strains of the laboratory mouse. BMC Research Notes, 1:125

Michael H. Kohn, Patricia J. Wittkopp. Annotating ebony on the fly. Molecular Ecology 14: 2831-2833.

Michael H. Kohn, William J. Murphy, Elaine A. Ostrander & Robert K. Wayne. Genomics and Conservation Genetics. Trends in Ecology & Evolution 21: 629-637.

Michael H Kohn, Roger E Price, Hans-Joachim Pelz. Mineralization of the arota in the Vkorc1 mutant warfarin-resistant rat (In review Blood)

M.H. Kohn, W.J. Murphy, E.A. Ostrander, and R.K. Wayne Genomics and convervation genetics.  Trends in Ecology and Evolution, 21 (11) 2006: 629-637

Naoki Osada*, Michael H. Kohn* & Chung-I Wu. Inference of cis-regulatory nucleotide polymorphism underlying gene expression differences between Drosophila melanogaster mating races. Molecular Biology & Evolution 23: 1585-1159. *authors contributed equally.

Michael H. Kohn, Shu Fang & Chung-I Wu Inference of positive and negative selection on the 5' regulatory regions of Drosophila genes.  Molecular Biology & Evolution, 21 2004: 374-383

Michael Kohn Lab

  • M.S. Molecular Ecology & Conservation (1994) Ludwig-Maximilians-Universitat Munchen, Department of Biology
  • Ph.D. Molecular Ecology , Molecular Population Genetics, Evolution (2000) University of California at Los Angeles, Department of Organismic Biology, Ecology & Evolution
  • Department of BioSciences
  • Ecology and Evolutionary Biology
  • Institute of Biosciences and Bioengineering
  • Keck Center for Quantitative Biomedical Sciences
  • Ken Kennedy Institute for Information Technology
  • Systems, Synthetic, and Physical Biology
  • Wiess School of Natural Sciences
Research Areas
  • Evolutionary biology, genomics, population genetics, conservation genetics, medical genetics
Professional Experience
  • Senior Research Fellow
    Center for Tropical Research, UCLA Institute of the Environment
  • Adjunct
    University of Texas, Graduate School Biomedical Sciences
  • Training Faculty
    Biomedical Discovery Training Program (BMDTP), Gulf Coast Consortia, Houston, Texas
  • Mellon-Mays Research Mentor
    Rice University
Contact Information
Email: hmkohn@rice.edu
Phone: 713-348-3779
Office: Anderson Biology Building, 205A