Rice University
BioSciences at Rice

Mary Farach-Carson

Adjunct Professor

Research in Dr. Farach-Carson's laboratory relates to the role of extracellular matrix in the progression of cancer following metastasis from primary sites, such as prostate or breast, to bone.  In many cases, primary tumors are fairly slow growing and do not become life-threatening until they form tumors in bone. The growth factors sequestered in bone matrix provide a very rich environment to promote the growth of cancer cells that invade there. Many of these growth factors are bound to a class of proteoglycans that contain heparan sulfate which regulate their bioactivity. Studies in the laboratory are aimed at identifying and isolating the growth factors responsible for cancer growth and progression with the long term aim of developing "molecular drugs" to combat cancer metastasis. Three dimensional models are used to study the behavior of cancer cells and to test their susceptibility to anti-cancer drugs that reduce cancer growth and progression. Industrial partnerships support the development of novel cancer diagnostics based on the principle that cancer biomarkers are created by cancer growth in bone.

A multidisciplinary project involves the use of proteoglycans, particularly those bearing heparan sulfate chains such as perlecan, in engineering of connective tissues such as bone, cartilage or salivary gland.
Cell and molecular engineering strategies are being developed that facilitate controlled tissue growth and differentiation. Growth factor binding and delivery by engineered proteoglycans is being used in oral surgery and orthopaedic applications. Several engineering partnerships both within and outside the university exist to support these studies.

A trainee doing research in this laboratory would be exposed to a variety of techniques including cell culture, recombinant and natural protein purification and analysis, calcium imaging, cloning and molecular biology, microRNAs, immunodetection and immunohistochemistry, and various pre-clinical cancer models.

Pubmed Search for articles by M Farach-Carson

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Fong, E.L.S., Wan, X., Yang, J., Morgado, M., Mikos, A.G., Harrington, D.A., Navone, N.M., Farach-Carson, M.C. A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interaction.  Biomaterials, 77 2016 : 164-72

Hubka, K.M., Wu, D., Harrington, D.A., Langer, J.C., Pocard, T., Jammayrac, O., Farach-Carson, M.C., Pradhan-Bhatt, S. Dissociative and non-dissociative models for culture of human eccrine glands for toxicology testing and tissue engineering applications.  Applied In Vitro Toxicology, 1 2015: 187-97

Warren, C.R., Kassir, E., Spurlin, J., Martinez, J., Putnam, N., Farach-Carson, M.C. Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis .  PLoS One, 10(4) 2015: e012578

Grigore, A.D., Ben-Jacob, E., Farach-Carson, M.C. Prostate Cancer and Neuroendocrine Differentiation: More Neuronal, Less Endocrine?.  Frontiers in Oncology, 5 2015: 37

Wijeratne, S.S., Martinez, J.R., Grindel, B.J., Frey, E.W., Li, J., Wang, L., Farach-Carson, M.C., Kiang, C.-W. Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix.  Matrix Biology 2015: (ePub ahead of print)

Farach, A., Teh, B.S., Chang, J.C., Farach-Carson, M.C., Butler, B. The role of combined radiation and immunotherapy in breast cancer treatment .  J Radiation Oncology, 4 2015: 347-354

Xu, X., Sabanayagam, C.R., Harrington, D.A., Farach-Carson, M.C., Jia, X. A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics.  Biomaterials, 35 2014: 3319-3330

Pradhan-Bhatt S., Harrington D.A., Duncan R.L., Farach-Carson, M.C., Jia X., Witt, R.L. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland” Laryngoscope.  Laryngoscope, 124 2014: 456-461

FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassman T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, et al. A promoter-level mammalian expression atlas. .  Nature, 507(7493) 2014: 462-70

Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium, Forrest AR, Carninci P, Rehli M, Sandelin A. An atlas of active enhancers across human cell types and tissues..  Nature, 507(7493) 2014: 455-61

Farach-Carson MC, Warren CR, Harrington DA, Carson DD. Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders..  Matrix Biol., 34 2014: 64-79

Hasegawa Y, Tang D, Takahashi N, Hayashizaki Y, Forrest AR; FANTOM Consortium, Suzuki H. CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes.  Sci Rep., 4 2014: 5228

Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, Lassmann T, Laurencikiene J, Rydén M, Arner P; FANTOM Consortium Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells. .  PLoS One, 9(3) 2014: e80274

Lowe, D.A., Lepori-Bui, N., Fomin, P.V., Sloofman, L.G., Zhou, X., Farach-Carson, M.C., Wang, L., Kirn-Safran, C.B. Deficiency of perlecan/HSPG2 during cartilage growth plate development enhances osteogenesis and decreases quality of adult bone in mice.  Calcified Tissue Int., 95(1) 2014: 29-38

Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.  Proc Natl Acad Sci U S A., 111(14) 2014: 5289-94

Dicker, K.T., Gurski, L.A., Pradhan-Bhatt, S., Witt, R.L., Farach-Carson, M.C. Jia, X. Hyaluronan: A simple polysaccharide with diverse biological function.  Acta Biomater, 10(4) 2014: 1558-70

Fong, E.L.S., Martinez, M., Yang, J., Mikos, A.G., Navone, N.M., Harrington, D.A., Farach-Carson, M.C. Hydrogel-based 3D model of patient-derived prostate xenograft tumors suitable for drug screening.  Molecular Pharmaceutics, 11(7) 2014: 2040-50

Chang MA, Patel V, Gwede M, Morgado M, Tomasevich K, Fong EL, Farach-Carson MC, Delk NA. IL-1β induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells.   J Cell Biochem., 115(12) 2014: 2188-97

Grindel, B.J., Martinez, J.R., Pennington, C.L., Muldoon, M., Stave, J., Chung, L.W. and Farach-Carson, M.C. Matrilysin/Matrix Metalloproteinase-7 (MMP7) cleavage of perlecan/HSPG2 produces bioactive fragments that alter prostate cancer cell behavior.  Matrix Biology, 36 2014: 64-76

Wang, B., Lai, X., Price, C., Thompson, W.R., Li, W., Quabili, T.R., Tseng, W-J., Liu, X., Zhang, H., Pan, J., Kirn-Safran, C.B., Farach-Carson, M.C., Wang, L. Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canilicular system.  J. Bone Min. Res., 29(4) 2014: 878-91

Warren, C.R., Grindel, B.J., Carson, D.D., Farach-Carson, M.C. Perlecan/HSPG2 increases in the desmoplastic prostate tumor microenvironment involve transcriptional activation by NFKB.  J. Cellular Biochemistry, 115(7) 2014: 1322-33

Chu, G.C., Zhau, H.E., Wang, R., Rogatko, A., Feng, X., Zayzafoon, M., Liu, Y., Farach-Carson, M.C., You, S., Kim, J., Freeman, M.R., Chung, L. RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization.  Endocr. Relat. Cancer, 21(2) 2014: 311-26

Xu X, Farach-Carson MC, Jia X. Three-dimensional in vitro tumor models for cancer research and drug evaluation.  Biotechnol Adv., 32(7) 2014: 1256-68

Fong, E.L.S., Santoro, M., Farach-Carson, M.C., Kasper, F.K., Mikos, A.G. Tissue engineering perfusable cancer models.   Current Opinion in Chemical Engineering: Biological engineering, 3 2014: 112-117

Chang, M., Morgado, M., Warren, C., Hinton, C.V., Farach-Carson, M.C., Delk, N. p62/SQSTM1 is required for cell survival of apoptosis-resistant metastatic prostate cancer cell lines.  The Prostate, 74 2014: 149-163

Chen, J., Lobachev, K.S., Grindel, B.J., Farach-Carson, M.C., Olivares-Navarrette, R., Doroudi, M., Boyan, B.D., Schwartz, Z. Chaperone properties of Pdia3 participate in rapid plasma membrane associated actions of 1α,25-dihydroxyvitamin D3 .  Molecular Endocrinology, 27 2013 Jul: 1065-77

Bhatt, S.P., Harrington, D.A., Duncan, R.L., Jia, X., Witt, R.L. Farach-Carson, M.C. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters.  Tissue Engineering, 9 (13-14) 2013: 1610-1620

Fong, E.L.S., Lamhamedi-Cherradi, S.E., Burdett, E., Ramamoorthy, V., Lazar, A., Kasper, F.K., Farach-Carson, M.C., Vishwamitra, D., Demicco, E.G., Menegaz, B.A., Amin, H.M., Ludwig, J.A., Mikos, A. Modeling Ewing's sarcoma tumors in vitro with 3D scaffolds .  Proc. Natl. Acad. Sci., 110 2013 : 6500-6505

Chung, S.-W., Cooper, C.R., Farach-Carson, M.C., and Ogunnaike, B.A. A control engineering approach to understanding the TGF-β paradox in cancer.  Journal of the Royal Society Interface, 9(71) 2012: 1389-97

Gurski, L.A., Xu, X., Labrada, L.N., Nguyen, N.T., Xiao, L., van Golen, K.L., Jia, X., Farach-Carson, M.C. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.  PLoS One, 7(11) 2012: e50075

Xu, X., Jha, J., Harrington, D.A., Farach-Carson, M.C., Jia, X. Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks.  Soft Matter, 8(12) 2012: 3280-3294

Srinivasan, P.P., McCoy, S.Y., Jha, A.K., Yang, W., Jia, X., Farach-Carson, M.C. and Kirn-Safran, C.B. Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a murine model of early osteoarthritis.  Biomedical Materials, 7(2) 2012: 024109

Delk,N., Farach-Carson, M.C. Interleukin-6: A bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells.  Autophagy, 8(4) 2012

Xu, X., Gurski, L.A., Zhang, Z., Harrington, D.A., Farach-Carson, M.C., Jia, X. Recreating the Tumor Microenvironment in a Bilayer, Hyaluronic Acid-Hydrogel Construct for Growth of Prostate Cancer Spheroids.  Biomaterials, 33(35) 2012: 9049-60

Warren, C.R. Ali-Khan Catts, Z., Farach-Carson, M.C. A new assay for functional screening of BRCA2 linker region mutations identifies variants that alter chemoresistance to cisplatin.  Exp. Cell Res., 317(15) 2011: 2099-109

Thompson, W.R., Majid, A.S., Czymmek, K.J., Ruff, A.L., Garcia, J., Duncan, R.L., Farach-Carson, M.C. Association of the α2δ1 Subunit with Cav3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes.  J. Bone Min. Research, 26(9) 2011: 2125-39

Boggs, M.E., Thompson, W.R., Farach-Carson, M.C., Duncan, R.L., Beebe. T.P. Co-culture of osteocytes and neurons on a unique patterned surface.  Biointerfaces, 6(4) 2011: 200

Zhang, C., Soori, M., Sikes, R.A., Carson, D.D., Chung, L.L.W., Farach-Carson, M.C. Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells.  The Prostate, 71(2) 2011: 157-67

Thompson, W.R., Modla, S., Grindel, B.J., Czymmek, K., Kirn-Safran, C.B., Wang, L. Duncan, R.L., Farach-Carson, M.C. Perlecan/Hspg2 deficiency alters the pericellular space of the lacuno-canalicular system surrounding osteocytic processes in cortical bone.  J. Bone Min. Research, 26(3) 2011: 618-629. (Top 2% article by Faculty of 1000)

Grindel, B.J., Rohe, B., Safford, S.E., Bennett, J.J., Farach-Carson, M.C. Tumor necrosis factor-α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,25D₃-MARRS to the nucleus.  J. Cell Biochem., 112(9) 2011: 2606-15

Wang, X. Gurski, L.A., Zhong, S. Xu, X., Pochan, D.J., Farach-Carson, M.C., Jia, X. Amphiphilic block copolyesters bearing pendant cyclic ketal groups as nanocarriers for controlled release of camptothecin.  Journal of Biomaterials Science: Polymer Edition , Epub ahead of print 2010

Hartman, O. Zhang, C., Adams, E.L., Farach-Carson, M.C., Petrelli, N.J., Chase, B.D. Rabolt, J.F. Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model.  Biomaterials, 31(21) 2010: 5700-18

Sloofman L.G., Verdelis K., Spevak L., Zayzafoon M., Yamauchi M., Opdenaker L.M., Farach-Carson M.C., Boskey A.L., Kirn-Safran C.B. Effect of HIP/ribosomal protein L29 deficiency on mineral properties of murine bones and teeth.  Bone, 47(1) 2010: 93-101

Thompson, W.R., Farach-Carson, M.C. Effects of 1,25-dihydroxyvitamin D3 on voltage sensitive calcium channels in osteoblast differentiation and morphology.  Vitamin D, Third Edition 2010

Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B., Rabolt, J.F. Fiber diameter controls osteoblastic cell migration and differentiation in electrospun gelatin.  Journal of Biomedical Materials Research Part A, 94(4) 2010: 1312-20

O'Connor, R.D., Farach-Carson, M.C., Schanen, N.C. Genetic and Epigenetic Aspects of Bone Development.  Topics in Bone Biology, 6 2010

Jha, A.K. Malik, M.S., Farach-Carson, M.C., Duncan, R.L., Jia, X. Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks.  Soft Matter, 6(20) 2010: 5045-55

Richard C.L., Farach-Carson M.C., Rohe B., Nemere I., Meckling K.A. Involvement of 1,25D3MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells.  Exp. Cell Res., 316(5) 2010: 695-703

Pradhan, S., Liu, C., Zhang, C., Jia, X., Farach-Carson, M.C., Witt, R. Lumen formation in 3D cultures of salivary acinar cells.  Otolaryngology & Head and Neck Surgery, 142(2) 2010: 191-5

Pradhan, S. and Farach-Carson M.C. Mining the extracellular matrix for tissue engineering applications.  Regen Med., 5(6) 2010: 961-70

Wu W., Beilhartz G., Roy Y., Richard C.L., Curtin M., Brown L., Cadieux D., Coppolino M., Farach-Carson M.C., Nemere I., Meckling K.A. Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFB in differentiating NB4 leukemia cells..  Exp. Cell Res., 316(7) 2010: 1101-8

Zhang, C., Soori, M., Miles F.L., Sikes, R.A., Carson, D.D., Chung, L.L.W., Farach-Carson, M.C. Paracrine factors produced by bone marrow stromal cells induce apoptosis and neuroendocrine differentiation in prostate cancer cells.  Prostate 2010 Jul 21

Gurski, L. A., Petrelli, N.J., Jia,X., Farach-Carson, M.C. Three-dimensional matrices for anti-cancer drug testing and development.  Association of Community Cancer Centers Oncology Issues: New Technologies, Jan/Feb 2010: 20-25

Witt, R.L., Jia, X., Liu, C., Zhang, C., Farach-Carson, M.C., Pradhan, S. Engineering an artificial salivary gland .  Otolaryngology - Head and Neck Surgery , 141 2009 September : P50

Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B., Rabolt, J.F. Evaluation of Cross-Linking Methods for Electrospun Gelatin on Cell Growth and Viability.  Biomacromolecules, 10 2009

Shao, Y., Czymmek, K., Fomin, V., Duncan, R.L., Farach-Carson, M.C. "Fluorescence resonance energy transfer (FRET) reveals dynamic interactions between L-type voltage sensitive calcium channel (VSCC) Cav 1.2 (alpha1C) subunits and ahnak in osteoblastic cells." AJP-Cell Physiol 296 (2009) C1067-1078.

Gurski, L., Jha, A.K., Zhang, C., Jia, X., Farach-Carson, M.C. Hyaluronic acid hydrogel as a scaffold for chemotherapeutic drug selection with poorly adherent cells.  Biomaterials, 30 2009: 6076-6085

O'Connor, R.D., Zayzafoon, M., Farach-Carson, M.C., Schanen, N.C. Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett Syndrome.  Bone, 45 2009: 346-356

Hartman O, Zhang C, Adams EL, Farach-Carson MC, Petrelli NJ, Chase BD, Rabolt JF Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications.  Biomacromolecules, 10 2009 Aug 10: 2019-32

Kirn-Safran, C., Farach-Carson, M.C., Carson, D.D. Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans.  Cellular and Molecular Life Sciences , 66 2009: 3421-3434

Pradhan, S.S., Zhang, C., Jia, X., Carson, D.D., Witt, R.L., Farach-Carson, M.C. Perlecan Domain IV Peptide Stimulates Salivary Gland Cell Assembly In Vitro.  Tissue Engineering Part A 2009 November : 3309-3320

Chung, S.-W., Miles, F.L., Sikes, R.A., Cooper, C.R., Farach-Carson, M.C., and Ogunnaike, B.A. Quantitative modeling and analysis of the transforming growth factor beta signaling pathway.  Biophys J , 96 2009: 1733-1750

Opdenaker, L.M., Farach-Carson, M.C. Rapamycin selectively reduces the association of transcripts containing complexes of 5' UTRs with the ribosome in prostate cancer cells .  J Cell Biochem, 107 2009: 473-481

Oristian, D.S., Sloofman, L.G., Zhou, X., Wang, L., Farach-Carson, M.C., Kirn-Safran, C.B. Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice.  J Orthop Res (cover), 27 2009: 28-35

Alcorn, J.L., Merritt, T.M., Farach-Carson, M.C., Wang, H.H., Hecht, J.T. Targeted reduction of mutant cartilage oligomeric matrix protein (COMP) using a COMP-specific ribozyme: a new strategy for gene therapy.  RNA, 15 2009: 686-695

D’Souza, S.S., Yang, W., Marchetti, D., Muir, C., Farach-Carson, M.C., and Carson, D.D. HIP/RPL29 antagonizes VEGF and FGF2 stimulated angiogenesis by interfering with HS-dependent responses.  J Cell Biochem, 105(5) 2008: 1183-1193

Farach-Carson, M.C., and Grindel, B. HSPG2 (heparan sulfate proteoglycan 2).  Atlas Genet Cytogenet Oncol Haematol 2008 October

Brown, A.J., Alicknavitch, M., D’Souza, S.S., Daikoku, T., Kirn-Safran, C., Marchetti, D., Carson, D.D., and Farach-Carson, M.C. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation.  Bone, 43(4) 2008: 689-699

Farach-Carson, M.C., Brown, A.J., Lynam, M., Safran, J.B., and Carson, D.D. A novel peptide sequence in perlecan domain IV supports cell adhesion and spreading.  Matrix Biology, 27 2007: 150-160

O’Connor, J.C., Farach-Carson, M.C., Schneider, C.J., and Carson, D.D. "Co-culture of bone marrow stromal cells with prostate cancer cells alters endoglin expression and attenuates TGF-β signaling in reactive bone stroma." Mol Cancer Res, 5(6) (2007) : 585-603.

Casper, C. L., Yang, W., Farach-Carson, M.C., Rabolt, J.F. Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding .  Biomacromolecules, 8(4) 2007: 1116-1123

Farach-Carson, M.C. and Carson, D.D. Perlecan: A multifunctional extracellular proteoglycan scaffold in embryo implantation and placentation.  Glycobiology, 17 2007: 897-905

Huang, W.C., Wu, D., Xie, Z., Zhau, H.E., Nomura, T., Zayzafoon, M., Pohl, J., Hsieh, C.L., Weitzmann, M.N., Farach-Carson, M.C., Chung, L.W. "β2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis." Cancer Res, 66(18) (2006) : 9108-9116.

Fong ELS, Wang X, Yang J, Morgado M, Mikos AG, Harrington DA, Navone NM, Farach-Carson MC. A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions. Biomaterials. (2015) 77:164-172

Farach-Carson BRC web page

  • Ph.D. Biochemistry (1982) Medical College of Virginia, Virginia Commonwealth Univ.
  • B.S. Biology (1978) University of South Carolina
  • Department of Bioengineering
  • Institute of Biosciences and Bioengineering
Research Areas
  • The role of extracellular matrix in the progression of cancer; the use of proteoglycans in the engineering of connective and glandular tissues
Contact Information
Email: farachca@rice.edu
Phone: 713-348-5052
Office: BRC, 140E