Rice University
BioSciences at Rice

Rosa Uribe

Assistant Professor

The Uribe lab research focuses on deciphering the genetic, cellular and signaling level mechanisms of neural crest stem cell proliferation, migration and cell -type differentiation during embryogenesis. Neural crest cells are a group of multipotent stem cell that migrate to various locations and give rise to many diverse cell types in the vertebrate body —such as pigment cells of the skin, cartilage, and neurons of the peripheral nervous system. Uribe's Research Currently, among various derivatives of the neural crest, we study how the largest division of the peripheral nervous system, the Enteric Nervous System (ENS), develops from the neural crest. During development, neural crest stem cells are specified and migrate ventrally away from the neural tube (precursor to central nervous system) and enter the primitive foregut tissue. They then migrate along the rostrocaudal extent of the gut in chains until they eventually reach the hindgut. These enteric neural crest cells (ENC) ultimately give rise to a diverse array of neurons and glia that make up the mature ENS, regulating such processes as gut peristalsis, water balance and hormone secretions. To investigate these processes in vivo, we utilize the model organism zebrafish, danio rerio, and a combination of genetic manipulations, drug studies, transgenesis, molecular biology, and live confocal and light sheet imaging. Currently, our research goals are to increase understanding of the signaling and genetic mechanisms that regulate the cell-fate specification and migration of neural crest cells during peripheral nervous system development. Ultimately, it is our overarching goal to enhance basic knowledge on the mechanisms that direct neural crest stem cell development and diversification in a tissue-specific context, leading to treatments for neural crest-derived diseases and cancers, affecting both children and adults world-wide.

Select Publications

RA Uribe, T Gu, ME Bronner. A novel subset of enteric neurons revealed by ptf1a: GFP in the developing zebrafish enteric nervous system.  Genesis 2016

RA Uribe, AL Buzzi, ME Bronner, PH Strobl-Mazzulla. Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression.  J Cell Biol , 211 2015: 815-827

J Lee, BD Cox, CMS Daly, C Lee, RJ Nuckels, RK Tittle, RA Uribe, ... An ENU Mutagenesis Screen in Zebrafish for Visual System Mutants Identifies a Novel Splice-Acceptor Site Mutation in patched2 that Results in Colobomas Zebrafish Visual System Mutations.  Investigative Ophthalmology & Visual Science , 53 2012: 8214-8221

RA Uribe, T Kwon, EM Marcotte, JM Gross. Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis.  Developmental Biology, 371 2012: 280-292

J Luo, RA Uribe, S Hayton, AA Calinescu, JM Gross, PF Hitchcock. Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina.  Neural Development, 7 2012: 33

RA Uribe, JM Gross. Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics.  Development, 137 2010: 3763-3774

RA Uribe, JM Gross. Id2 is essential for regulating growth and patterning of the vertebrate retina.  Developmental Biology, 331 2009: 388

A Ng, RA Uribe, L Yieh, R Nuckels, JM Gross. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.  Development, 136 2009: 2601-2611

RA Uribe, JM Gross. Immunohistochemistry on cryosections from embryonic and adult zebrafish eyes.  CSH Protoc 2007: 4779

Uribe Lab Web Page

  • Ph.D. Molecular Cell and Developmental Biology (2012) University of Texas
  • B.S. Cell and Molecular Biology (2006) San Francisco State University
    Research Areas
    • Developmental Biology, Zebrafish, Neuron, Cancer
    Professional Experience
    • Postdoctoral Scholar
      California Institute of Technology
    Contact Information
    Email: Rosa.Uribe@rice.edu
    Phone: 713-348-4169
    Office: George R. Brown, W200